First Name
Corree
Last Name
Laule
Position
Associate Member
Office Room
818 West 10th Ave - VGH ICORD
Tel (Office)
(604) 675-8855
Email
claule@phas.ubc.ca
Research Groups

Students Wanted
willing to supervise



Doctoral Degree
University of British Columbia, 2005, Ph.D. in Physics

Hobbies and Interests

science communication, animals, gardening, hiking, pilates & yoga, cooking, vegetarian and vegan food, hanging out with my husband and our 2 bunnies.


Research Area
Medical Physics

Research Field
magnetic resonance imaging

Research Topics
myelin water imaging, quantitative MRI, T1 and T2 relaxation, brain, spinal cord, myelin, histology, lipids, multiple sclerosis, spinal cord injury, neurological diseases

Abstract

I have been using NMR and MRI to conduct brain and spinal cord research for over two decades, with an emphasis on myelin imaging. After a PhD in MR physics, I completed a post-doctoral fellowship in neuropathology where my research focused on MRI-pathology correlation studies in multiple sclerosis (MS) brain tissue. I am is now an Associate Professor at UBC, and an Associate Director of the International Collaboration on Repair Discoveries (ICORD).  I am interested in understanding the microstructural and pathological determinants which govern MRI signal changes in central nervous system (CNS) tissue. My primary areas of research are MS and spinal cord injury, and I have extensive experience in imaging both in vivo and post mortem brain and spinal cord. I have also has conducted research many other CNS applications including schizophrenia, cervical spondylotic myelopathy, PKU, Krabbe Disease, Hungtington's Disease, depression, brain tumours, vascular cognitive impairment, development, aging, dyslexia, and dyscalculia, as well the characterization of normal controls. I am particularly interested in myelin and hope to use biochemical analysis and electron microscopy to understand how variations in myelin composition and structure may influence to MRI measures. 


Selected Publications

Laule, C, Yung A, Pavolva V, Bohnet B, Kozlowski P, Hashimoto SA, Yip S, Li DK, Moore GRW. High-resolution myelin water imaging in post-mortem multiple sclerosis spinal cord: A case report. Multiple Sclerosis. 2016 Oct;22(11):1485-1489.

Laule C and MacKay AL. Magnetic Resonance of Myelin Water: An in vivo Marker for Myelin. Brain Plasticity. 2016 (2)1: pp. 71-91. (Invited Review)

Barta R, Kalantari S, Laule C, Vavasour IM, MacKay AL, Michal CA. Modeling T1 and T2 relaxation in bovine white matter. J Magn Reson. 2015 Oct;259:56-67

Laule CPavlova V, Leung E, Zhao G, MacKay AL, Kozlowski P, Traboulsee AL, Li DKB, Moore GRW. Diffusely Abnormal White Matter in Multiple Sclerosis: Further Histological Studies Provide Evidence for a Primary Lipid Abnormality with Neurodegeneration. Journal of Neuropathology and Experimental Neurology, 2013 Jan;72(1):42-52

Meyers SM, Vavasour IM, M├Ądler B, Harris T, Fu E, Li DK, Traboulsee AL, Mackay AL, Laule C. Multicenter measurements of myelin water fraction and geometric mean T2 : Intra- and intersite reproducibility. Journal of Magnetic Resonance Imaging, 2013 Dec;38(6):1445-53

Moore GRW and Laule C. Neuropathologic Correlates of Magnetic Resonance Imaging in Multiple Sclerosis. Journal of Neuropathology and Experimental Neurology. 2012 Sep;71(9):762-778 (Invited Review)

Kalantari S, Laule C, Bjarnason TA, MacKay AL. In-vivo insights into magnetization exchange in human white matter structures. Magnetic Resonance in Medicine 2011 Oct; 66(4) 1142-1151

Laule C, Vavasour IM, Leung E, Li DKB, Kozlowski P, Traboulsee AL, Oger J, MacKay AL, Moore GRW. Pathological Basis of Diffusely Abnormal White Matter: Insights from Magnetic Resonance Imaging and Histology. Multiple Sclerosis 2011 Feb;17(2): 144-150

Laule C, Vavasour IM, Vavasour JD, Oger J, Paty DW, MacKay AL, Li DKB. Cervical Cord Abnormalities in Primary Progressive Multiple Sclerosis: Atrophy and Myelin Water Changes. Mult Scler. 2010 Jun;16(6):670-677

Laule C, Tahir S, Chia CLL, Vavasour IM, Kitson N, MacKay AL. A proton NMR study on the hydration of normal versus psoriatic stratum corneum: linking distinguishable reservoirs to anatomical structures NMR Biomed. 2010 Dec;23(10):1181-1190

Laule C, Vavasour IM, Kolind SH, Li DK, Traboulsee TL, Moore GR, Mackay AL. Magnetic resonance imaging of myelin. Neurotherapeutics 2007;4(3):460-484. (Invited Review)

Laule C, Vavasour IM, Moore GRW, Oger J, Li DKB, Paty DW, MacKay AL. Water content and myelin water fraction in multiple sclerosis: A T2 relaxation study. Journal of Neurology 2004;251(3):284-293.