First Name
Corree
Last Name
Laule
Position
Associate Member
Office Room
818 West 10th Ave - VGH ICORD
Tel (Office)
(604) 675-8855
Email
claule@phas.ubc.ca
Research Groups

Students Wanted
willing to supervise


Doctoral Degree
University of British Columbia, 2005, Ph.D. in Physics

Hobbies and Interests

science communication, gardening, hiking, pilates & yoga, cooking, eating sushi, hanging out with my husband and our 2 bunnies.


Research Area
Medical Physics

Research Field
myelin water imaging, quantitative MRI, T1 and T2 relaxation, brain, spinal cord, myelin, histology, lipids, multiple sclerosis, spinal cord injury, neurological diseases

Abstract

I am interested in understanding the microstructural and pathological determinants which govern T1 and T2 relaxation measures in central nervous system (CNS) tissue. I am a physicist and have been involved with NMR and MRI research for 19 years. I completed a post-doctoral fellowship in the Department of Pathology & Laboratory Medicine where my research focused on MRI pathology correlation studies in multiple sclerosis (MS) brain tissue. My primary area of research is MS and I have extensive experience in imaging both in vivo and post mortem MS brain and spinal cord, with emphasis on characterizing myelin. I also collaborates to study many other CNS applications including schizophrenia, cerebral malaria, bipolar disorder, leukodystrophies and Huntington’s disease, as well the characterization of normal controls. I am particularly interested in myelin and plan to use biochemical analysis and electron microscopy to understand how variations in myelin composition/structure may influence to MRI measures.


Selected Publications

Laule, C, Yung A, Pavolva V, Bohnet B, Kozlowski P, Hashimoto SA, Yip S, Li DK, Moore GRW. High-resolution myelin water imaging in post-mortem multiple sclerosis spinal cord: A case report. Multiple Sclerosis. 2016 Oct;22(11):1485-1489.

Laule C and MacKay AL. Magnetic Resonance of Myelin Water: An in vivo Marker for Myelin. Brain Plasticity. 2016 (2)1: pp. 71-91. (Invited Review)

Barta R, Kalantari S, Laule C, Vavasour IM, MacKay AL, Michal CA. Modeling T1 and T2 relaxation in bovine white matter. J Magn Reson. 2015 Oct;259:56-67

Laule CPavlova V, Leung E, Zhao G, MacKay AL, Kozlowski P, Traboulsee AL, Li DKB, Moore GRW. Diffusely Abnormal White Matter in Multiple Sclerosis: Further Histological Studies Provide Evidence for a Primary Lipid Abnormality with Neurodegeneration. Journal of Neuropathology and Experimental Neurology, 2013 Jan;72(1):42-52

Meyers SM, Vavasour IM, Mädler B, Harris T, Fu E, Li DK, Traboulsee AL, Mackay AL, Laule C. Multicenter measurements of myelin water fraction and geometric mean T2 : Intra- and intersite reproducibility. Journal of Magnetic Resonance Imaging, 2013 Dec;38(6):1445-53

Moore GRW and Laule C. Neuropathologic Correlates of Magnetic Resonance Imaging in Multiple Sclerosis. Journal of Neuropathology and Experimental Neurology. 2012 Sep;71(9):762-778 (Invited Review)

Kalantari S, Laule C, Bjarnason TA, MacKay AL. In-vivo insights into magnetization exchange in human white matter structures. Magnetic Resonance in Medicine 2011 Oct; 66(4) 1142-1151

Laule C, Vavasour IM, Leung E, Li DKB, Kozlowski P, Traboulsee AL, Oger J, MacKay AL, Moore GRW. Pathological Basis of Diffusely Abnormal White Matter: Insights from Magnetic Resonance Imaging and Histology. Multiple Sclerosis 2011 Feb;17(2): 144-150

Laule C, Vavasour IM, Vavasour JD, Oger J, Paty DW, MacKay AL, Li DKB. Cervical Cord Abnormalities in Primary Progressive Multiple Sclerosis: Atrophy and Myelin Water Changes. Mult Scler. 2010 Jun;16(6):670-677

Laule C, Tahir S, Chia CLL, Vavasour IM, Kitson N, MacKay AL. A proton NMR study on the hydration of normal versus psoriatic stratum corneum: linking distinguishable reservoirs to anatomical structures NMR Biomed. 2010 Dec;23(10):1181-1190

Laule C, Vavasour IM, Kolind SH, Li DK, Traboulsee TL, Moore GR, Mackay AL. Magnetic resonance imaging of myelin. Neurotherapeutics 2007;4(3):460-484. (Invited Review)

Laule C, Vavasour IM, Moore GRW, Oger J, Li DKB, Paty DW, MacKay AL. Water content and myelin water fraction in multiple sclerosis: A T2 relaxation study. Journal of Neurology 2004;251(3):284-293.