Profile picture for user mandre
First Name
Andre
Last Name
Marziali
Position
Professor
Office Room
ChemPhys 039
Lab Room
ChemPhys 039/041/043
Tel (Office)
(604) 822-5489
Tel (Lab)
(604) 822-4514
Email
andre@physics.ubc.ca
Research Groups
Applied Physics
Students Wanted
not accepting
Research Website
Research Website
Additional Links
Boreal Genomics
Bachelor's Degree
University of British Columbia, Vancouver, BC, B.A.Sc. in Engineering Physics
Doctoral Degree
Stanford University, Stanford, CA, Ph.D. in Physics
Employment History
President and CSO, Boreal Genomics 2007 - present
Director, UBC Engineering Physics 2007 - present
Professor, UBC Physics and Astronomy 2010 - present
Associate Michael Smith Laboratories, UBC 1999 - present
Associate Professor, UBC Physics and Astronomy 2005  -2010
Assistant Professor, UBC Physics and 1998 - 2005
Lead Research Engineer, Stanford DNA Sequence Technology Ctr. 1994-1998
Awards
  • Margaret Fulton Award for Student Development, UBC, Mar 2016
  • Life Science BC – Innovation and Achievement Award, 2011
  • Association for Lab Automation Innovation Award, 2007
  • CAP Medal for Excellence in Teaching, Mar, 2005
  • BC Innovation Council – Young Innovator Award, 2004
  • Killam Award for Excellence in Teaching, Mar, 2003
Research Area
Biophysics
Research Field
Biophysics - Genomics Technologies
Selected Publications
  1. Kidess, Evelyn, Kyra Heirich, Matthew Wiggin, Valentina Vysotskaia, Brendan C. Visser, Andre Marziali, Bertram Wiedenmann et al. "Mutation profiling of tumor DNA from plasma and tumor tissue of colorectal cancer patients with a novel, high-sensitivity multiplexed mutation detection platform." Oncotarget 6, no. 4 (2015): 2549.
  2. Steven F. Buchsbaum, Nick Mitchell, Hugh Martin, Matt Wiggin, Andre Marziali, Peter V. Coveney, Zuzanna Siwy, and Stefan Howorka, “Disentangling Steric and Electrostatic Factors in Nanoscale Transport Through Confined Space” Nano Lett., 2013, 13 (8), pp 3890–3896
  3. Nahid N. Jetha, Valentyna Semenchenko, David S. Wishart, Neil R. Cashman, Andre Marziali, “Nanopore Analysis of Wild-Type and Mutant Prion Protein (PrPC): Single Molecule Discrimination and PrPC Kinetics”,  PLOS One, 7 February 2013 , Volume 8 , Issue 2 , e54982
  4. Joseph M. Dahl, Ai H. Mai, Gerald M. Cherf, Nahid N. Jetha, Daniel R. Garalde, Andre Marziali, Mark Akeson, Hongyun Wang, and Kate R. Lieberman “Direct observation of translocation  in individual DNA polymerase complexes", Journal of Biological Chemistry, APRIL 13, 2012•VOLUME 287•NUMBER 16
  5. Jason D. Thompson1, Gosuke Shibahara2, Sweta Rajan2, Joel Pel2, Andre Marziali, “Winnowing DNA for rare sequences: highly specific sequence and methylation based enrichment”, PLOS One, February 2012 , Volume 7, Issue 2
  6. Nahid N. Jetha, Christopher Feehan, Matthew Wiggin, Vincent Tabard-Cossa, and Andre Marziali, “Long dwell time passage of DNA through nanometer-scale pores: Kinetics and sequence dependence of motion”, Biophysical Journal, Volume 100, June 2011 2974–2980
  7. Radu I. Stefureac, Dhruti Trivedi, Andre Marziali and Jeremy S. Lee, “Evidence that small proteins translocate through silicon nitride pores in a folded conformation.” J. Phys.: Condens. Matter 22 (2010) 454133 (10pp)
  8. Austin So, Joel Pel,Sweta Rajan, and Andre Marziali “Efficient Genomic DNA Extraction from Low Target Concentration Bacterial Cultures using SCODA DNA Extraction Technology” Cold Spring Harb Protoc. 10; 2010
  9. Tabard-Cossa, Vincent; Wiggin, Matthew; Trivedi, Dhruti; Jetha, Nahid; Dwyer, Jason; and Marziali, Andre,  “Single Molecule Bonds Characterized by Solid-State Nanopore Force Spectroscopy”, ACS NANO   Volume: 3   Issue: 10   Pages: 3009-3014   2009
  10. Joel Pel1, David Broemeling1, Laura Mai1, Hau-Ling Poon2, Giorgia Tropini1 Rene L. Warren3, Robert A. Holt3, and Andre Marziali1 “Non-linear Electrophoretic Response Yields a New Parameter for Separation of Biomolecules”, PNAS  Volume: 106   Issue: 35   Pages: 14796-14801   2009
  11. *Daniel Branton1, David Deamer2, Andre Marziali3, Hagan Bayley4, Steven A. Benner5, Thomas Butler6, Massimiliano Di Ventra7, Slaven Garaj8, Andrew Hibbs9, Xiaohua Huang10, Stevan B Jovanovich11, Predrag S. Krstic12, Stuart Lindsay13, Xinsheng Sean Ling14, Carlos H. Mastrangelo15, Amit Meller16, John S. Oliver17, Yuriy V. Pershin7, J. Michael Ramsey18, Robert Riehn19, Gautam V. Soni16, Vincent Tabard-Cossa3, Meni Wanunu16, Matthew Wiggin20, Jeffery A. Schloss21, “Nanopore Sequencing”, Nature Biotechnology, Volume 26, Number 10, 1146-1153, Oct 2008. *** I initiated the idea for this publication with Jeff Schloss, and was one of the three editors (with Branton and Deamer)
  12. Matthew Wiggin, Carolina Tropini, Vincent Tabard-Cossa, Nahid N. Jetha, and Andre Marziali “Non-exponential kinetics of DNA escape from a-Hemolysin nanopores”,  Biophysical Journal, 2008, Volume: 95   Issue: 11   Pages: 5317-5323  
  13. David J. Broemeling, Joel Pel, Dylan C. Gunn, Laura Mai, Jason D. Thompson, Hiron Poon, Andre Marziali “An Instrument for Automated Purification of Nucleic Acids from Contaminated Forensic Samples”, Journal of the Association for Laboratory Automation, Volume 13, Issue 1, Pages 40-48 (February 2008)
  14. Dylan Gunn1*, Jared Slobodan1*, Cheyenne Kamran1, Justin Tzou1, David Broemeling1, Diponkar Banerjee2 and Andre Marziali , “A Novel Applicator Design for Contact-Free Delivery of Aqueous Reagent to Individual Biopsies in a Tissue Microarray”, Journal of the Association for Laboratory Automation, Volume 12, Issue 5, Pages 277-283, 2007
  15. *Vincent Tabard-Cossa, Dhruti Trivedi, Matthew Wiggin, Nahid N Jetha and Andre Marziali “Noise analysis and reduction in solid-state nanopores”, Nanotechnology, 18 (2007) 305505
  16. Jared Slobodan, Dylan Gunn, Jason Thompson, Kurtis Guggenheimer, Keddie Brown, Mark Homenuke, Roy Belak, Diponkar Banerjee, David Broemeling, and Andre Marziali, “An Automated Nanoliter Dispenser for Tissue Microarrays”, Int J Oncol 30: 857-863, 2007
  17. *Carolina Tropini and Andre Marziali, “Multi-nanopore force spectroscopy for DNA analysis”, Biophysical Journal, 2007 92: 1632-1637
  18. Elisabeth Maurer-Spurej, Keddie Brown, Audrey Labrie, Andre Marziali and Otto Glatter, “Portable dynamic light scattering instrument and method for the measurement of concentrated cell suspensions”, PHYSICS IN MEDICINE AND BIOLOGY 51 (15): 3747-3758 AUG 7 2006
  19. N. Jetha and A. Marziali, “Liquid handling technology and the method of electrostatic drop transfer to improve dispensing”, invited paper, Journal of the Association for Laboratory Automation, JALA Aug 2006;11:278–80
  20. N. Jetha and A. Marziali, “An Electrostatic Device For Active Transfer Of Sub-Microliter Samples From Syringe Pipettors”, BioTechniques, 40 (2): 148+ FEB 2006
  21. Duane E Smailus, Marco A Marra, Andre Marziali, Robert A Holt, “Simple, robust methods for high-throughput nanoliter-scale DNA sequencing”, Genome Research, 2005, 15: 1447 - 1450
  22. R. Coope, A. Marziali, “Contaminant-induced current decline in capillary array electrophoresis”, Electrophoresis, 2005, 26, 11, 2128-2137
  23. *A. Marziali, J. Pel, D. Bizzotto1, L. Whitehead, “Novel Electrophoresis Mechanism Based On Synchronous Alternating Drag Perturbation” Electrophoresis, 2005, 26, 82-90
  24. *J. Nakane, M. Wiggin, A. Marziali, “A nano-sensor for trans-membrane capture and identification of single nucleic acid molecules” Biophysical Journal, 87: 615-621 July 2004.
  25. Martin Krzywinski1, John Wallis2, Claudia Gösele3,4, Ian Bosdet1, Readman Chiu1, Tina Graves2, Oliver Hummel3, Dan Layman2, Carrie Mathewson1, Natasja Wye1, Baoli Zhu5, Derek Albracht2, Jennifer Asano1, Sarah Barber1, Mabel Brown-John1, Susanna Chan1, Steve Chand1, Alison Cloutier1, Jonathon Davito2, Chris Fjell1, Tony Gaige2, Detlev Ganten3, Noreen Girn1, Kurtis Guggenheimer, Heinz Himmelbauer4, Thomas Kreitler3,4, Stephen Leach1, Darlene Lee1, Hans Lehrach4, Andre Marziali, Michael Mayo1, Kelly Mead2, Teika Olson1, Pawan Pandoh1, Anna-Liisa Prabhu1, Heesun Shin1, Jason Thompson, Miranda Tsai1, Jason Walker2, George Yang1, Mandeep Sekhon2, LaDeana Hillier2, Heike Zimdahl3,4, Kazutoyo Osoegawa5, Shaying Zhao6, Asim Siddiqui1, Pieter J. de Jong5, Wes Warren2, Elaine Mardis2, John D. McPherson2, Rick Wilson2, Norbert Hübner3, Steven Jones1, Marco Marra1, Jacqueline Schein1,7, “Integrated and Sequence-Ordered BAC and YAC-based Physical Maps for the Rat Genome”, Genome Research, 14 (4): 766-779 APR 2004
  26. J. Nakane, M. Akeson, and A. Marziali, “Nanopore sensors for macromolecule analysis”, invited review for Journal of Physics: Condensed Matter, 2003, 15: R1365–R1393
  27. J. Thompson, T. Pugh, K. Guggenheimer, A. Safarpour, A. Christie, J. Pel, S. Chow, A. Marziali, “Facilitated Loading Of Horizontal Gels Using A Capillary Gel Comb”, BioTechniques, 2003, 34:814-818
  28. Wenonah A. Vercoutere , Stephen Winters-Hilt, Veronica S. DeGuzman, David Deamer , Sam Ridino , Joseph T. Rodgers, Hugh E. Olsen , Andre Marziali, and Mark Akeson, Discrimination Among Individual Watson-Crick Base-Pairs at the Termini of Single DNA Hairpin Molecules”  Nucleic Acids Research, 2003, Vol. 31, 4, 1311-1318
  29. Greg Vatcher, Duane Smailus, Martin Krzywinski, Ran Guin, Jeff Stott, Miranda Tsai, Susanna Chan, Pawan Pandoh, George Yang, Jennifer Asano, Teika Olson, Anna-Liisa Prabhu, Robin Coope, Andre Marziali, Jacquie Schein, Steven Jones, and Marco Marra, “Resuspension of DNA Sequencing Reaction Products in Agarose Increases Sequence Quality on an Automated Sequencer”,  BioTechniques, 2002 Sep;33(3):532-4, 536, 538-9
  30. J.Nakane, M. Akeson, A. Marziali,  “Evaluation of nanopores as candidates for electronic analyte detection”, invited submission, Electrophoresis 2002, 23,2592–2601
  31. A. Marziali and M. Akeson, " New DNA Sequencing Methods", Annu. Rev. of Biomed. Eng. 2001, 3:195-223.
  32. Jonathan Nakane, David Broemeling, Roger Donaldson, Andre Marziali, Thomas D. Willis, Matthew O’Keefe, and Ronald W. Davis**, "A Method For Parallel, Automated, Thermal Cycling Of  Sub-Microliter Samples", Genome Res. 2001 11: 441-447. 2601 ** The author list on this paper was an error by the journal and they concatenated the two institution author lists, which were intended to be listed separately. I should be last author, and the work was carried out almost entirely at UBC.
  33. *Athanasios Theologis, Joseph R. Ecker, Curtis J. Palm, Nancy A. Federspiel, Samir Kaul, Owen White, Jose Alonso,Hootan Alta, Rina Araujo, Cheryl L. Bowman, Shelise Y. Brooks,Eugen Buehler, April Chan, Qimin Chao, Huaming Chen, Rosa F. Cheuk, Christina W. Chin, Mike K. Chung, Lane Conn, Aaron B. Conway, Andrew R. Conway, Todd H. Creasy, Ken Dewar,Patrick Dunn, Pelin Etgu, Tamara V. Feldblyum, Ji Dong Feng, BettyFong, ClaireY.Fujii, John E. Gill, Andrew D. Goldsmith, BrianHaas, Nancy F. Hansen, Beth Hughes, Lucas Huizar, Jonathan L. Hunter, Jennifer Jenkins, Chanda Johnson-Hopson, Shehnaz Khan, Elizabeth Khaykin, Christopher J. Kim, Hean L. Koo, Irina Kremenetskaia, David B. Kurtz, Andrea Kwan, Bao Lam, Stephanie Langin-Hooper, Andrew Lee, Jeong M. Lee, Catherine A. Lenz, Joycelyn. H. Li, YaPing Li, Xiaoying Lin, Shirley X. Liu, Zhaoying A. Liu, Jason S. Luros, Rama Maiti, Andre Marziali, Jennifer Militscher, Molly Miranda, Michelle Nguyen, William C. Nierman, Brian I. Osborne, Grace Pai, Jeremy Peterson, Paul K. Pham, Michael Rizzo, Timothy Rooney, Don Rowley, Hitomi Sakano, Steven L. Salzberg, Jody R. Schwartz, Paul Shinn, Audrey M. Southwick, Hui Sun, Luke J. Tallon, Gabriel Tambunga, Mitsue J. Toriumi, Christopher D. Town, Teresa Utterback, Susan Van Aken, Maria Vaysberg, Valentina S. Vysotskaia, Michelle Walker, Dongying Wu, Guixia Yu, Claire M. Fraser, J. Craig Venter & Ronald W. Davis, “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana”, Nature 408, 816 - 820 (2000)
  34. Andre Marziali, Thomas D. Willis, Nancy A. Federspiel, and Ronald W. Davis, “An Automated Sample Preparation System for Large Scale DNA Sequencing” Genome Res. 1999 9: 457-462.
  35. Andre Marziali, Thomas D. Willis, and Ronald W. Davis, “An Arrayable Flow-Through Microcentrifuge for High Throughput Instrumentation”,Proc. Natl. Acad. Sci. USA 1999 Jan 5;96(1):61‑66 (this paper elicited a commentary: “Laue, T.M., “An arrayable flow-through microcentrifuge for high-throughput instrumentation–a matter of scale”,Proc. Natl. Acad. Sci. USA Vol. 96, p. 1163, February 1999)
  36.  A. Marziali, Nancy Federspiel, and Ron Davis, “Automation for the Arabidopsis Genome Sequencing Project”, Trends in Plant Science, Feb. 1997, Vol. 2, No. 2.
  37.  A. Marziali and T.I. Smith, "Demonstration of Wavelength Stabilization in a Free Electron Laser",  I.E.E.E. Journal of Quantum Electronics, vol. 30, no.9, September 1994.
  38.  A. Marziali, H.A. Schwettman, J.G. Hatmaker, M.W. Hiller, H.G. Cambell, R. Sinko, M.W. Hamilton, C.G. Coghill, R. Dunham, J.L. Light, Carroll Allcock, "Fabrication Methods of the Superconducting Injector Cavities for the Stanford University Free Electron Laser", I.E.E.E. Trans. Magn., 27(2) p1916, March 1991.