Add to Calendar 2024-11-21T16:00:00 2024-11-21T17:00:00 Biophysical models of cell motion in confined geometries - from single-cell to collective dynamics Event Information: Abstract: Living cells move and change shape through forces created by a network of proteins inside them called the cytoskeleton. Scientists use biophysical models to study how this internal system makes cells move. A major challenge is understanding how the behavior of individual cells connects to the collective movement of many cells. In this study, we look at how single cells move along narrow tracks and in circular patterns using time-lapse imaging. These artificial patterns help control where the cells move and allow us to track many cells at once. We present models that explain how cells move, how their shapes change over time, and how they transition between different movement behaviors. Our findings show that mechanical models can explain universal patterns observed across different types of cells, such as the relationship between how strongly cells stick to surfaces and how fast they move. We also discuss how standardized tests can help measure cell movement and how simulations can improve our understanding of cell migration behaviors. Bio: Dr. Sabrina Leslie PHAS faculty and Director of the Leslie Labs is pleased to host an expert in single-cell imaging, Dr. Joachim Rädler from Munich, for this MSL Seminar Series and PHAS Colloquium. Joachim is a world-recognized physicist, with an h-index of 67, who has advanced single-cell imaging and connects with biology and genomics. He's uniquely at a crossover between physics and biology, as well as stem cell therapeutics. Learn More: See Dr. Rädler's faculty contact page from LMU: https://www.physik.lmu.de/softmatter/en/people/contact-page/joachim-raedler-cd971327.html What is soft matter physics? https://www.physik.lmu.de/softmatter/en/      Event Location: HENN 201