Alpha-Particle Radiotherapy and a Microdosimetric Approach to Multiscale Modeling

Event Date:
2026-02-23T11:00:00
2026-02-23T12:00:00
Event Location:
HENN 318
Speaker:
Mirta Dumancic, McGill University
URL:
Zoom link
Related Upcoming Events:
Other Talks
Intended Audience:
Everyone
Local Contact:

ZOOM Meeting URL:     https://ubc.zoom.us/j/67987040037?pwd=O7NlZ7BKD2rKDbSTW0shLdwQdTJe1D.1

  • Meeting ID:        679 8704 0037
  • Passcode:            052600
Event Information:

Abstract: 

Microdosimetry plays a central role in modeling the Relative Biological Effectiveness (RBE) of ionizing radiation in cancer therapy, particularly for high-LET sources. This seminar presents recent results from in vivo experiments and physics-based modeling of Diffusing Alpha-Emitters Radiation Therapy (DaRT). In addition, a novel microdosimetric framework based on Geant4 Monte Carlo simulations, developed at McGill University, will be introduced and positioned within a multiscale radiobiological modeling approach. Finally, various radiobiological endpoints will be examined as potential biomarkers of intrinsic radiosensitivity in cancer patients and as directions for future research.

Bio: 

Dr. Mirta Dumancic is a medical physics researcher specializing in novel therapies, microdosimetry, and multiscale modeling in radiobiology. She recently completed her postdoctoral training at McGill University’s Medical Physics Unit, where her research focused on alpha-particle radiotherapy and the integration of physics-based modeling with biological response. Her work integrates Monte Carlo modeling using Geant4 with microdosimetric approaches to investigate energy deposition at multiple spatial scales and its implications for biological outcomes in cancer cells.

Links:

 

Add to Calendar 2026-02-23T11:00:00 2026-02-23T12:00:00 Alpha-Particle Radiotherapy and a Microdosimetric Approach to Multiscale Modeling Event Information: Abstract:  Microdosimetry plays a central role in modeling the Relative Biological Effectiveness (RBE) of ionizing radiation in cancer therapy, particularly for high-LET sources. This seminar presents recent results from in vivo experiments and physics-based modeling of Diffusing Alpha-Emitters Radiation Therapy (DaRT). In addition, a novel microdosimetric framework based on Geant4 Monte Carlo simulations, developed at McGill University, will be introduced and positioned within a multiscale radiobiological modeling approach. Finally, various radiobiological endpoints will be examined as potential biomarkers of intrinsic radiosensitivity in cancer patients and as directions for future research. Bio:  Dr. Mirta Dumancic is a medical physics researcher specializing in novel therapies, microdosimetry, and multiscale modeling in radiobiology. She recently completed her postdoctoral training at McGill University’s Medical Physics Unit, where her research focused on alpha-particle radiotherapy and the integration of physics-based modeling with biological response. Her work integrates Monte Carlo modeling using Geant4 with microdosimetric approaches to investigate energy deposition at multiple spatial scales and its implications for biological outcomes in cancer cells. Links: View her website: Mirta Dumancic Read this article: Kudos to Mirta Dumancic for Dual Conference Awards • EngerLab   Event Location: HENN 318