UBC Logo Steven Samuel Plotkin, Associate Professor at UBC
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Welcome to the website for the Plotkin Research Group!

We do research at the interface of biology and physics.

Our current projects involve the molecular-genetic study of the evolution of multicellularity, protein misfolding in neurodegenerative disease, and more recently, viral evolution and molecular therapeutics to SARS-CoV-2. Please see our Research Page for more details! (Group picture below is pre-pandemic.)

Plotkin Group News:

Recently Awarded Grants:

Recent Publications:

  • Peng X, Gibbs, E, Silverman JM, Cashman NR and Plotkin SS "A Method for Systematically Ranking Therapeutic Drug Candidates Using Multiple Uncertain Screening Criteria" Statistical Methods in Medical Research https://doi.org/10.1177/09622802211002861 (2021)

Recent Submissions:

  • Hsueh S, Nijlad M, Peng X, , Aina A, Hilton B, and Plotkin"First Principles Calculation of Protein-Protein Dimer Affinites of ALS-Associated SOD1 Mutants" (submitted)
  • Hsueh S CC, Aina A, Cashman NR, Peng X and Plotkin SS  "Epitope Scaffolding Using α-synuclein Cyclic Peptides to Generate Oligomer-selective Antibodies for Parkinson’s Disease" (submitted)
  • Garg P, Semmler S, Baudouin C, Vande Velde C, Plotkin SS "Misfolding-Associated Exposure of Natively Buried Residues in Mutant SOD1 Facilitates Binding to TRAF6" (submitted)
  • Pokrishevsky E, DuVal MG, McAlary L, Louadi S, Pozzi S, Roman A, Plotkin SS, Dijkstra A, Julien JP, Allison WT, Cashman NR "Tryptophan Residues in TDP-43 and SOD1 Mediate the Cross-seeding and Toxicity of SOD1" (submitted)
  • DuVal MG, McAlary L, Habibi M, Garg P, Sher M, Cashman NR, Allison WT and Plotkin SS "Physical Properties of Novel Aggressive and Beneficial SOD1 Mutants Predict Phenotypes Consistent with ALS" (posted on bioRxiv)

Recent Recorded Presentations:


We are grateful to the Digital Technology Supercluster, Canadian Institutes of Health Research, Alberta Innovates and the Alberta Prion Research Institute, and Westgrid/Compute Canada for supporting our research.


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