Departmental Oral Examination (Thesis Title: "Measurement of the Arterial Input Function from Radial MR Projections")

Event Start:
Event End:
Event Location:
Room 318, Hennings Bldg.
Intended Audience:
Public
Speaker:
JENNIFER MOROZ
Local Contact:

Physics and Astronomy

Event Information:

Abstract:
DCE-MRI provides a non-invasive method to probe the health status of tissue and help identify diseases, such as cancer.  Biologically relevant information is extracted by fitting the data to a pharmacokinetic model.  The accuracy of the fit parameters is highly sensitive to the quality of the input curves: the contrast-time curve in the tissue of interest, and the arterial input function, which characterizes the contrast kinetics of a blood vessel feeding the tissue.  The AIF is difficult to measure in pre-clinical studies in mice due to their small body size and limited number of vessels of sufficient size. As a result, several groups use a population averaged AIF from the literature.  This curve does not account for inter or intra individual differences, and is specific to a particular injection protocol.

This thesis presents a projection-based measurement that measures the AIF from a single trajectory in k-space, which provides a temporal resolution equal to the repetition time (TR).  The projection-based AIF allows for acquisition of DCE-MRI data between successive measurements, while maintaining a high temporal resolution of both data sets.  A dual-coil experimental platform is set up to acquire a projection-based AIF in the mouse tail, concurrently with DCE-MRI data at a tumour implanted on the hind flank.  The results show that an AIF, with a temporal resolution of 100 ms, may be acquired in the mouse tail.  Using this curve in the model fit provided K_trans = 0.145 min^-1, and v_e = 0.269.  These values are consistent with other studies involving tumours.

Add to Calendar Event Start: Friday, April 26, 2019 - 2:00 pm Event End: 5:00 pm Departmental Oral Examination (Thesis Title: "Measurement of the Arterial Input Function from Radial MR Projections") Event Information: Abstract: DCE-MRI provides a non-invasive method to probe the health status of tissue and help identify diseases, such as cancer.  Biologically relevant information is extracted by fitting the data to a pharmacokinetic model.  The accuracy of the fit parameters is highly sensitive to the quality of the input curves: the contrast-time curve in the tissue of interest, and the arterial input function, which characterizes the contrast kinetics of a blood vessel feeding the tissue.  The AIF is difficult to measure in pre-clinical studies in mice due to their small body size and limited number of vessels of sufficient size. As a result, several groups use a population averaged AIF from the literature.  This curve does not account for inter or intra individual differences, and is specific to a particular injection protocol. This thesis presents a projection-based measurement that measures the AIF from a single trajectory in k-space, which provides a temporal resolution equal to the repetition time (TR).  The projection-based AIF allows for acquisition of DCE-MRI data between successive measurements, while maintaining a high temporal resolution of both data sets.  A dual-coil experimental platform is set up to acquire a projection-based AIF in the mouse tail, concurrently with DCE-MRI data at a tumour implanted on the hind flank.  The results show that an AIF, with a temporal resolution of 100 ms, may be acquired in the mouse tail.  Using this curve in the model fit provided K_trans = 0.145 min^-1, and v_e = 0.269.  These values are consistent with other studies involving tumours. Event Location: Room 318, Hennings Bldg.

Source URL: https://phas.ubc.ca/departmental-oral-examination-thesis-title-measurement-arterial-input-function-radial-mr